A suppository, which is a general term for a solid dose of medicine that is inserted into the anus or the vagina, can contain different medications, from contraceptives to medication to kill off yeast infections. Glycerinated Gelatin Polyethylene Glycols. 6. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. weight is dependent upon the density of the drug, but mainly the density of the base - adult rectal suppositories are shaped as torpedo, bullet, or finger with a rectal dose weight about 2 grams when cocoa butter is used as a base - children rectal suppositories are more pencil shaped and about half the weight of the adult dose (1 gram) Hard fat suppository bases melt at approximately body temperature. Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API. Also called. Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. https://medical-dictionary.thefreedictionary.com/Suppository+bases. So, by the addition of the drug , 1 gm of the suppository base is displaced. Name the Oleaginous Suppository Bases that are Cocoa Butter substitutes. Suppository definition, a solid, conical mass of medicinal substance that melts upon insertion into the rectum or vagina. A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. The selection of a suppository base is dependent upon a number of physicochemical variables, including the solubility characteristics of the drug. Tableted suppositories or inserts. 67. It may be used to stimulate a bowel movement, but often serves as a vehicle for medicines to be absorbed. A medicinal substance that slowly dissolves after being inserted into the rectum (or other body cavity). Glycerinated Gelatin is a useful suppository base, particularly for vaginal suppositories. Some mixtures and bases have very pronounced contractions (e.g., cocoa butter, PEG) while others have much smaller ones (e.g., glycerinated gelatin, MBK®). Surfactant base. ry. Water soluble/water miscible bases are those containing glycerinated gelatin or the polyethylene glycol (PEG) polymers. What is the main advantage of a polyethylene glycol Suppository Base over Oleaginous Bases? Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Wecobee Witepsol. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. ( sŭ-poz'i-tō'rē ), A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. Hydrophilic suppository bases also melt at body temperature, and … These products are so formulated that after insertion, they will either melt or dissolve in … A lipophilic drug that is distributed in a fatty suppository base in low concentration has less of a tendency to escape to the surrounding aqueous fluids than a hydrophilic drug in its saturation concentrations. Learn more. Learn more. Vaginal suppositories are one method of administering a drug to treat a specific disease or condition, or for contraceptive purposes. As the warmth of your body melts the … Definition of suppository : a solid but readily meltable cone or cylinder of usually medicated material for insertion into a bodily passage or cavity (such as the rectum) Examples of suppository in a Sentence Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. See more. •A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to A suppository is a medication that is inserted into the rectum, vagina, or urethra to be broken down and absorbed by the body. The shape, volume and consistency of suppositories are suitable for rectal application. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. © 2003-2012 Princeton University, Farlex Inc. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Suppository bases usually employed are cocoa butter, glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of PEG (15). Such a hole is undesirable. See more. Physical or chemical in- compatibilities with other constituents may be predicted if the exact formula composition is known including preservatives, antioxidants and emulsifiers There are three types of suppositories, each to insert into a different sections: Rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male. This is then poured into the mold, refrigerated to harden, cut into pieces the size of the patient's pinky finger, and inserted as needed. suppository meaning: a small, solid pill containing a drug that is put inside the anus, where it dissolves easily. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. supposition meaning: 1. the fact of believing something is true without any proof or something that you believe to be…. Suppository uses include asthma, allergies, and pain. SUPPOSITORY BASE Lipid–Water Solubility •The lipid–water partition coefficient of a drug is an important consideration in the selection of the suppository base and in anticipating drug release from that base. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. 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